The Wasps wing/full-back pulled up just before half-time of Saturday's 14-9 victory at Stade de France in Paris.
The 30-year-old was sent for a scan on Sunday night which confirmed that he had suffered a grade one strain.
A brief statement from the Rugby Football Union (RFU) confirmed: "He [Lewsey] will take no further part in the tournament and will be replaced in the 30-man squad. The replacement is under consideration."
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