Out half Niall O'Connor and winger Mark McCrea's inclusion, is the only change to the squad, from the 22 who faced Leinster at the RDS last Sunday.
Talking out Friday's match, Matt Williams said: "The Ospreys are a fantastic team, a brilliant team and physically they are a massive side.
"No-one expects us to win. Everyone has written us off, everyone says we can't do it, so this is a week when there is not a lot of pressure on us, and that is a good thing," said Williams.
Not considered due to injury: Stephen Ferris, Bryn Cunningham, Paul Steinmetz.
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Ulster squad named for Ospreys Magners League clash
Ulster squad named for Ospreys Magners League clash
