London Irish blitzed the Dragons at Rodney Parade to record their second successive Pool One bonus-point win.
Tomas De Vedia (2), Mike Catt and Delon Armitage secured the crucial four tries inside half-an-hour, before the shell shocked home side got a Mike Owen try.
That was little comfort as Catt and Peter Richards ran the show, Peter Hewat kicking superbly for 15 points.
Nick Kennedy and Armitage crossed after the break, against a consolation Dragons score from hooker Steve Jones.
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